Salt-N-Pepa perform a medley of their hits at UrbanAID in 1995.

Hip hop legends Salt-N-Pepa have supported Lifebeat from the very beginning of the organization.

In June of 1992, the first ladies of hip hop performed at the very first Lifebeat fundraising concert at Roseland Ballroom in Manhattan, headlining along with the Pet Shop Boys.

In October 1995, Salt-N-Pepa performed at the first UrbanAID at Madison Square Garden along with the Wu-Tang Clan, Naughty by Nature, Run-D.M.C., the Notorious B.I.G., Craig Mack, Junior M.A.F.I.A., Fat Joe, Jodeci, Mary J. Blige and Brandy.

In 2007, Lifebeat was featured on an episode of The Salt-N-Pepa show on Vh1. The girls recorded a new PSA for Lifebeat during the show as well.

Lifebeat hosted the official book launch party in 2008 for Let’s Talk About Pep, Sandy “Pepa” Denton’s autobiography, at HOME nightclub in NYC. The evening was a fundraiser for Lifebeat.

In February 2011, Lifebeat teamed up with Salt-N-Pepa once again, conducting outreach to distribute condoms and safer sex information and educate fans at stops on the Legends of Hip-Hip Tour they headlined.